Published Covers
Yu, M., S. Stott, M. Toner, S. Maheswaran, and D. A. Haber, "Circulating tumor cells: approaches to isolation and characterization," J Cell Biol 192(3):373-382, 2011. |
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Stott S.L.*, Lee R.J.*, Nagrath S.*, Yu M., Miyamoto D.T., Ulkus L., Inserra E.J., Ulman M., Springer S., Nakamura Z., Moore A.L.,Tsukrov D.I., Kempner M.E., Dahl D.M., Wu C.L., Iafrate A.J., Smith M.R., Tompkins R.G., Sequist L.V., Toner M., Haber D.A., Maheswaran S., "Isolation and characterization of circulating tumor cells from patients with localized metastatic prostate cancer," Science Translational Medicine 2(25):25, 2010. |
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Mittal, S., I. Y. Wong, W. M. Deen, and M. Toner, "Antibody-functionalized fluid-permeable surfaces for rolling cell capture at high flow rates," Biophys J 102(4):721-730, 2012. |
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Scherber, C., A. J. Aranyosi, B. Kulemann, S. P. Thayer, M. Toner, O. Iliopoulos, and D. Irimia, "Epithelial cell guidance by self-generated EGF gradients," Integr Biol 4:259-269, 2012. doi: 10.1039/C2IB00106C » |
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Watkins, N. N., S. Sridhar, X. Cheng, G. D. Chen, M. Toner, W. Rodriguez, and R. Bashir, "A microfabricated electrical differential counter for the selective enumeration of CD4+ T lymphocytes," Lab Chip 11:1437-1447, 2011. doi: 10.1039/C0LC00556H » |
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Watkins, N., B. M. Venkatesan, M. Toner, W. Rodriguez, and R. Bashir, "A robust electrical microcytometer with 3-dimensional hydrofocusing," Lab Chip 9:3177-3184, 2009.
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Irimia, D. and M. Toner, "Spontaneous migration of cancer cells under conditions of mechanical confinement," Integr Biol 1:506-512, 2009. doi: 10.1039/B908595E » |
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Miyamoto, D. T., R. J. Lee, S. L. Stott, D. T. Ting, B. S. Wittner, M. Ulman, M. E. Smas, J. B. Lord, B. W. Brannigan, J. Trautwein, N. H. Bander, C-L. Wu, L. V. Sequist, M. R. Smith, S. Ramaswamy, M. Toner, S. Maheswaran, and D. A. Haber, "Androgen Receptor Signaling in Circulating Tumor Cells as a Marker of Hormonally Responsive Prostate Cancer," Canc Discov 2:995-1003, 2012. |
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Park, K., J. Jang, D. Irimia, J. Sturgis, J. Lee, J. P. Robinson, M. Toner, and R. Bashir, "'Living cantilever arrays' for characterization of mass of single live cells in fluids," Lab Chip 8:1034-1041, 2008. doi: 10.1039/B803601B » |
Books & Chapters
Annual Reviews of Biomedical EngineeringMartin Yarmush, Editor. The highest impact factor (11.6) among all biomedical engineering publications, and the second highest among all engineering journals. |
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Methods in Bioengineering: Micro- and Nanoengineering of the Cell Microenvironment: Technologies and Applicationsby Ali Khademhosseini, Jeffrey Borenstein, Mehmet Toner and Suichi Takayama |
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Methods in Bioengineering: Microdevices in Biology and Medicineby Yaakov Nahmias, Sangeeta Bhatia |
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Methods in Bioengineering: Organ Preservation and Reengineeringby Korkut Uygun, Charles Y. Lee |
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Methods in Bioengineering: Biomicrofabrication and Biomicrofluidicsby Jeffrey D. Zahn |
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Methods in Bioengineering: Stem Cell Bioengineeringby Biju Parekkadan and Martin Yarmush |
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Methods in Bioengineering: Systems Analysis of Biological Networksby Arul Jayaraman and Juergen Hahn |
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Methods in Bioengineering: Nanoscale Bioengineering and Nanomedicineby Kaushal Rege and Igor L. Medintz |
Journals
2014
- Hamza B, Wong E, Patel S, Cho H, Martel JM and Irimia D. Retrotaxis of Human Neutrophils during Mechanical Confinement inside Microfluidic Channels. Integrative Biology, 2014, 6, 175.
- Cho H*, Hamza B*, Wong E, and Irimia D. On-demand Competing Gradient Arrays for Neutrophil Chemotaxis. Lab on a Chip, 2014. 14. 972
- Karabacak NM, Spuhler PS, Fachin F, Lim EJ, Pai V, Ozkumur E, Martel JM, Kojic N, Smith K, Chen P, Yang J, Hwang H, Morgan B, Trautwein J, Barber TA, Stott SL, Maheswaran S, Kapur R, Haber DA and Toner M. Tumor Antigen-Independent Isolation of Circulating Tumor Cells from Clinical Blood Samples. Nature Protocols. In Press
- Hoang AN, Jones CN, Dimisko L, Hamza B, Martel JM, Kojik N and Irimia D. Microfluidic Platform for Measuring Neutrophil Chemotaxis from Unprocessed Whole Blood. Journal of Visualized Experiments, In Press
- Martel JM and Toner M. Inertial Focusing in Microfluidics. Annual Reviews of Biomedical Engineering, In Press
- Boneschansker L, Yan J, Wong E, Briscoe DM, Irimia D. Microfluidic platform for the quantitative analysis of leukocyte migration signatures. Nature Communications 2014 Sep 3;5:4787. DOI: 10.1038/ncomms5778
- Wong IY, Javaid S, Wong EA, Perk S, Haber DA, Tomer M, Irimia D. Collective and individual migration following the epithelial-mesenchymal transition. Nature Mater. 2014 Aug 17. DOI: 10.1038/nmat4062
- Jones CN, Hoang AN, Dimisko L, Hamza B, Martel J. Irimia D. Microfluidic platform for measuring neutrophil chemotaxis from unprocessed whole blood. J Vis Exp. 2014 Jun 3;(88). DOI: 10.3791/51215
2013
- Kurihara T, Jones CN, Yu YM, Fischman AJ, Watada S, Tompkins RG, Fagan S, Irimia D. (2013) Resolvin D2 Restores Neutrophil Directionality and Improves Survival after Burns. FASEB Journal 27, 2270-2281. DOI: 10.1096/fj.12-219519 »
- Bohr S, Patel SJ, Sarin D, Irimia D, Yarmush ML, Berthiaume F. (2013) Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. Wound Repair Regen 21(1), 35-43. DOI: 10.1111/j.1524-475X.2012.00853.x »
- Mittal, S., Wong, I.Y., Yanik, A.A., Deen, W.M., Toner, M. (2013) Discontinuous nanoporous membranes reduce non-specific fouling for immunoaffinity cell capture. Small, online. 9(24), 4207–4214 (2013) DOI: 10.1002/smll.201300977 »
- Mantel, P-Y., Hoang, AN., Goldowitz I., Potashnikova, D., Hamza, B., Vorobjev, I., Ghiran, I., Toner, M., Irimia, D., Ivanov, AR., Barteneva N., Marti, M. (2013) Malaria-Infected Erythrocyte-Derived Microvesicles Mediate Cellular Communication within the Parasite Population and with the Host Immune System. Cell Host & Microbe 13(5), 521-534. DOI: 10.1016/j.chom.2013.04.009 »
- Cho, H., Hashimoto, T., Wong, EA., Zhao, L., Hori, Y., Wood, LB., Haigis, KM., Hyman, BT., Irimia, D. (2013) Microfluidic Chemotaxis Platform for Differentiating the Distinct Roles of Soluble and Bound Amyloid-β on Microglial Accumulation. Sci Rep 3, 1823. DOI: 10.1038/srep01823 »
- Desai, SP., Bhatia, SN., Toner, M., Irimia, D. (2013) Mitochondrial Localization and the Persistent Migration of Epithelial Cancer Cells. Biophys J 104(9), 2077-2088. DOI: 10.1016/j.bpj.2013.03.025 »
- Liong, M., Hoang, AN*., Chung, J., Gural, N., Ford, CB., Min, C., Shah, RR., Fernandez-Suarez, M., Fortune, SM., Toner, M., Hakho, L., Weissleder, R. (2013) Point-of-Care Magnetic Barcode Assay for Genetic Pathogen Detection. Nature Communications, in press.
- Yu. M., Bardia, A., Wittner, B.S., Stott, S.L., Smas, M.E., Ting D.T., Isakoff, S.J., Ciciliano, J.C., Wells, M.N., Shah, A.M., Concannon, K.F., Donaldson, M.C., Sequist, L.V., Brachtel, E., Sgroi, D., Baselga, J., Ramaswamy, S., Toner, M., Haber, D.A., and Maheswaran, S., (2013) Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition. Science 339(6119):580-584. DOI: 10.1126/science.1228522 »
- Ozkumur, E., Shah, A. M., Ciciliano, J. C., Emmink, B. L., Miyamoto, D. T., Brachtel, E., Yu, M., Chen, P.-I, Morgan, B., Trautwein, J., Kimura, A., Sengupta, S., Stott, S. L., Karabacak, N. M., Barber, T. A., Walsh, J. R., Smith, K., Spuhler, P. S., Sullivan, J. P., Lee, R. J., Ting, D. T., Luo, X., Shaw, A. T., Bardia, A., Sequist, L. V., Lewis, D. N., Maheswaran, S., Kapur, R., Haber, D. A., and Toner, M., (2013) Inertial Focusing for Tumor Antigen-Dependent and -Independent Sorting of Rare Circulating Tumor Cells. Science Translational Medicine 5(179):179ra47. DOI: 10.1126/scitranslmed.3005616 »
2012
- Jones, C.N., Dalli, J., Dimisko, L., Wong, E., Serhan, C.N., and Irimia, D. (2012) RNA Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. Proc Nat Acad Sci USA 109(50), 20560-20565. DOI: 10.1073/pnas.1210269109 »
- Yu, M., Ting, D. T., Stott, S. L., Wittner, B. S., Ozsolak, F., Paul, S., Ciciliano, J. C., Smas, M. E., Winokur, D., Gilman, A. J., Ulman, M. J., Xega, K., Contino, G., Alagesan, B., Brannigan, B. W., Milos, P. M., Ryan, D. P., Sequist, L. V., Bardeesy, N., Ramaswamy, S., Toner, M., Maheswaran, S., and Haber, D. A. (2012) RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis. Nature 487, 510-513
- Oh, S. F., Dona, M., Fredman, G., Krishnamoorthy, S., Irimia, D., and Serhan, C. N. (2012) Resolvin E2 Formation and Impact in Inflammation Resolution. J Immunol
- Miyamoto, D. T., Lee, R. J., Stott, S. L., Ting, D. T., Wittner, B. S., Ulman, M., Smas, M. E., Lord, J. B., Brannigan, B. W., Trautwein, J., Bander, N. H., Wu, C. L., Sequist, L. V., Smith, M. R., Ramaswamy, S., Toner, M., Maheswaran, S., and Haber, D. A. (2012) Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer. Cancer Discov 2, 995-1003
- Lee, J., Li, M., Milwid, J., Dunham, J., Vinegoni, C., Gorbatov, R., Iwamoto, Y., Wang, F., Shen, K., Hatfield, K., Enger, M., Shafiee, S., McCormack, E., Ebert, B. L., Weissleder, R., Yarmush, M. L., and Parekkadan, B. (2012) Implantable microenvironments to attract hematopoietic stem/cancer cells. Proc Natl Acad Sci USA 109, 19638-19643
- El-Haibi, C. P., Bell, G. W., Zhang, J., Collmann, A. Y., Wood, D., Scherber, C. M., Csizmadia, E., Mariani, O., Zhu, C., Campagne, A., Toner, M., Bhatia, S. N., Irimia, D., Vincent-Salomon, A., and Karnoub, A. E. (2012) Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. Proc Natl Acad Sci USA 109, 17460-17465
- Chen, A., Yarmush, M. L., and Maguire, T. (2012) Physiologically based pharmacokinetic models: integration of in silico approaches with micro cell culture analogues. Curr Drug Metab 13, 863-880
- Aldridge, B. B., Fernandez-Suarez, M., Heller, D., Ambravaneswaran, V., Irimia, D., Toner, M., and Fortune, S. M. (2012) Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility. Science 335, 100-104
- Xu, C., Poh, Y. K., Roes, I., O'Cearbhaill, E. D., Matthiesen, M. E., Mu, L., Yang, S. Y., Miranda-Nieves, D., Irimia, D., and Karp, J. M. (2012) A portable chemotaxis platform for short and long term analysis. PLoS One 7, e44995
- Ritch, J. J., Valencia, A., Alexander, J., Sapp, E., Gatune, L., Sangrey, G. R., Sinha, S., Scherber, C. M., Zeitlin, S., Sadri-Vakili, G., Irimia, D., Difiglia, M., and Kegel, K. B. (2012) Multiple phenotypes in Huntington disease mouse neural stem cells. Mol Cell Neurosci 50, 70-81
- Shah, A. M., Yu, M., Nakamura, Z., Ciciliano, J., Ulman, M., Kotz, K., Stott, S. L., Maheswaran, S., Haber, D. A., and Toner, M. (2012) Biopolymer system for cell recovery from microfluidic cell capture devices. Anal Chem 84, 3682-3688
- Seker, E., Berdichevsky, Y., Staley, K. J., and Yarmush, M. L. (2012) Microfabrication-compatible nanoporous gold foams as biomaterials for drug delivery. Adv Healthc Mater 1, 172-176
- Scherber, C., Aranyosi, A. J., Kulemann, B., Thayer, S. P., Toner, M., Iliopoulos, O., and Irimia, D. (2012) Epithelial cell guidance by self-generated EGF gradients. Integr Biol (Camb) 4, 259-269
- Mittal, S., Wong, I. Y., Deen, W. M., and Toner, M. (2012) Antibody-functionalized fluid-permeable surfaces for rolling cell capture at high flow rates. Biophys J 102, 721-730
- Martel, J. M., and Toner, M. (2012) Inertial focusing dynamics in spiral microchannels. Phys Fluids (1994) 24, 32001
- Lim, E. J., Ober, T. J., Edd, J. F., McKinley, G. H., and Toner, M. (2012) Visualization of microscale particle focusing in diluted and whole blood using particle trajectory analysis. Lab Chip 12, 2199-2210
- Lee, J., Li, M., Milwid, J., Dunham, J., Vinegoni, C., Gorbatov, R., Iwamoto, Y., Wang, F., Shen, K., Hatfield, K., Enger, M., Shafiee, S., McCormack, E., Ebert, B. L., Weissleder, R., Yarmush, M. L., and Parekkadan, B. (2012) Implantable microenvironments to attract hematopoietic stem/cancer cells. Proc Natl Acad Sci USA 109, 19638-19643
- Jones, C. N., Dalli, J., Dimisko, L., Wong, E., Serhan, C. N., and Irimia, D. (2012) Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. Proc Natl Acad Sci USA 109, 20560-20565
- Gao, S., Seker, E., Casali, M., Wang, F., Bale, S. S., Price, G. M., and Yarmush, M. L. (2012) Ex vivo gene delivery to hepatocytes: techniques, challenges, and underlying mechanisms. Ann Biomed Eng 40, 1851-1861
- El-Haibi, C. P., Bell, G. W., Zhang, J., Collmann, A. Y., Wood, D., Scherber, C. M., Csizmadia, E., Mariani, O., Zhu, C., Campagne, A., Toner, M., Bhatia, S. N., Irimia, D., Vincent-Salomon, A., and Karnoub, A. E. (2012) Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. Proc Natl Acad Sci USA 109, 17460-17465
- Dolle, J. P., Morrison Iii, B., Schloss, R. S., and Yarmush, M. L. (2012) An organotypic uniaxial strain model using microfluidics. Lab Chip 13, 432-442
- Chen, G. D., Fachin, F., Colombini, E., Wardle, B. L., and Toner, M. (2012) Nanoporous micro-element arrays for particle interception in microfluidic cell separation. Lab Chip 12, 3159-3167
- Aldridge, B. B., Fernandez-Suarez, M., Heller, D., Ambravaneswaran, V., Irimia, D., Toner, M., and Fortune, S. M. (2012) Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility. Science 335, 100-104
2011
- Rosenbach, A. E., Koria, P., Goverman, J., Kotz, K. T., Gupta, A., Yu, M., Fagan, S. P., Irimia, D., and Tompkins, R. G. (2011) Microfluidics for T- lymphocyte cell separation and inflammation monitoring in burn patients. Clin Transl Sci 4, 63-68
- Yu, M., Stott, S., Toner, M., Maheswaran, S., and Haber, D. A. (2011) Circulating tumor cells: approaches to isolation and characterization. J Cell Biol 192, 373-382
- Yang, R., Fredman, G., Krishnamoorthy, S., Agrawal, N., Irimia, D., Piomelli, D., and Serhan, C. N. (2011) Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. J Biol Chem 286, 31532-31541
- Watkins, N. N., Sridhar, S., Cheng, X., Chen, G. D., Toner, M., Rodriguez, W., and Bashir, R. (2011) A microfabricated electrical differential counter for the selective enumeration of CD4+ T lymphocytes. Lab Chip 11, 1437-1447
- Watkins, N., Irimia, D., Toner, M., and Bashir, R. (2011) On a chip. IEEE Pulse 2, 19-27
- Liong, M., Fernandez-Suarez, M., Issadore, D., Min, C., Tassa, C., Reiner, T., Fortune, S. M., Toner, M., Lee, H., and Weissleder, R. (2011) Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance. Bioconjug Chem 22, 2390-2394
- Warner, E. A., Kotz, K. T., Ungaro, R. F., Abouhamze, A. S., Lopez, M. C., Cuenca, A. G., Kelly-Scumpia, K. M., Moreno, C., O'Malley, K. A., Lanz, J. D., Baker, H. V., Martin, L. C., Toner, M., Tompkins, R. G., Efron, P. A., and Moldawer, L. L. (2011) Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage. Lab Invest 91, 1787-1795
- Li, M., Tilles, A. W., Milwid, J. M., Hammad, M., Lee, J., Yarmush, M. L., and Parekkadan, B. (2011) Phenotypic and functional characterization of human bone marrow stromal cells in hollow-fibre bioreactors. J Tissue Eng Regen Med
- Kenar, H., Kose, G. T., Toner, M., Kaplan, D. L., and Hasirci, V. (2011) A 3D aligned microfibrous myocardial tissue construct cultured under transient perfusion. Biomaterials 32, 5320-5329
- Hoerning, A., Koss, K., Datta, D., Boneschansker, L., Jones, C. N., Wong, I. Y., Irimia, D., Calzadilla, K., Benitez, F., Hoyer, P. F., Harmon, W. E., and Briscoe, D. M. (2011) Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3. Eur J Immunol 41, 2291-2302
- Warner, E. A., Kotz, K. T., Ungaro, R. F., Abouhamze, A. S., Lopez, M. C., Cuenca, A. G., Kelly-Scumpia, K. M., Moreno, C., O'Malley, K. A., Lanz, J. D., Baker, H. V., Martin, L. C., Toner, M., Tompkins, R. G., Efron, P. A., and Moldawer, L. L. (2011) Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage. Lab Invest 91, 1787-1795
- Seker, E., Sung, J. H., Shuler, M. L., and Yarmush, M. L. (2011) Solving medical problems with BioMEMS. IEEE Pulse 2, 51-59
- Rosenbach, A. E., Koria, P., Goverman, J., Kotz, K. T., Gupta, A., Yu, M., Fagan, S. P., Irimia, D., and Tompkins, R. G. (2011) Microfluidics for T- lymphocyte cell separation and inflammation monitoring in burn patients. Clin Transl Sci 4, 63-68
- Konry, T., Smolina, I., Yarmush, J. M., Irimia, D., and Yarmush, M. L. (2011) Ultrasensitive detection of low-abundance surface-marker protein using isothermal rolling circle amplification in a microfluidic nanoliter platform. Small 7, 395-400
- Kenar, H., Kose, G. T., Toner, M., Kaplan, D. L., and Hasirci, V. (2011) A 3D aligned microfibrous myocardial tissue construct cultured under transient perfusion. Biomaterials 32, 5320-5329
- Hoerning, A., Koss, K., Datta, D., Boneschansker, L., Jones, C. N., Wong, I. Y., Irimia, D., Calzadilla, K., Benitez, F., Hoyer, P. F., Harmon, W. E., and Briscoe, D. M. (2011) Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3. Eur J Immunol 41, 2291-2302
- Chen, G. D., Fachin, F., Fernandez-Suarez, M., Wardle, B. L., and Toner, M. (2011) Nanoporous elements in microfluidics for multiscale manipulation of bioparticles. Small 7, 1061-1067
2010
- Wolfer, A., Wittner, B. S., Irimia, D., Flavin, R. J., Lupien, M., Gunawardane, R. N., Meyer, C. A., Lightcap, E. S., Tamayo, P., Mesirov, J. P., Liu, X. S., Shioda, T., Toner, M., Loda, M., Brown, M., Brugge, J. S., and Ramaswamy, S. (2010) MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proc Natl Acad Sci USA 107, 3698-3703
- Stott, S. L., Lee, R. J., Nagrath, S., Yu, M., Miyamoto, D. T., Ulkus, L., Inserra, E. J., Ulman, M., Springer, S., Nakamura, Z., Moore, A. L., Tsukrov, D. I., Kempner, M. E., Dahl, D. M., Wu, C. L., Iafrate, A. J., Smith, M. R., Tompkins, R. G., Sequist, L. V., Toner, M., Haber, D. A., and Maheswaran, S. (2010) Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer. Sci Transl Med 2, 25ra23
- Seker, E., Berdichevsky, Y., Begley, M. R., Reed, M. L., Staley, K. J., and Yarmush, M. L. (2010) The fabrication of low-impedance nanoporous gold multiple-electrode arrays for neural electrophysiology studies. Nanotechnology 21, 125504
- Oakey, J., Applegate, R. W., Jr., Arellano, E., Di Carlo, D., Graves, S. W., and Toner, M. (2010) Particle focusing in staged inertial microfluidic devices for flow cytometry. Anal Chem 82, 3862-3867
- Novik, E., Maguire, T. J., Chao, P., Cheng, K. C., and Yarmush, M. L. (2010) A microfluidic hepatic coculture platform for cell-based drug metabolism studies. Biochem Pharmacol 79, 1036-1044
- Irimia, D. (2010) Microfluidic Technologies for Temporal Perturbations of Chemotaxis. Annu Rev Biomed Eng 12, 259-284.
- Cho, C. H., Park, J., Tilles, A. W., Berthiaume, F., Toner, M., and Yarmush, M. L. (2010) Layered patterning of hepatocytes in co-culture systems using microfabricated stencils. Biotechniques 48, 47-52
- Chen, G. D., Alberts, C. J., Rodriguez, W., and Toner, M. (2010) Concentration and purification of human immunodeficiency virus type 1 virions by microfluidic separation of superparamagnetic nanoparticles. Anal Chem 82, 723-728
- Chen, C., Skog, J., Hsu, C. H., Lessard, R. T., Balaj, L., Wurdinger, T., Carter, B. S., Breakefield, X. O., Toner, M., and Irimia, D. (2010) Microfluidic isolation and transcriptome analysis of serum microvesicles. Lab Chip 10, 505-511
- Shannon L. Stott, Chia-Hsien Hsu, Dina I. Tsukrov, Min Yu, David T. Miyamoto, Belinda A. Waltman, S. Michael Rothenberg, Ajay M. Shah, Malgorzata E. Smas, George K. Korir, Frederick P. Floyd, Jr., Anna J. Gilman, Jenna B. Lord, Daniel Winokur, Simeon Springer, Daniel Irimia, Sunitha Nagrath, Lecia V. Sequist, Richard J. Lee, Kurt J. Isselbacher, Shyamala Maheswaran, Daniel A. Haber, and Mehmet Toner. Isolation of circulating tumor cells using a microvortex-generating herringbone-chip.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(43):18392-18397, OCT 26 2010. [ DOI ]
- Harrison Prentice-Mott, Mehmet Toner, and Daniel Irimia. Microfluidic proportional flow controller. JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 20(11), NOV 2010. [ DOI ]
- Vijayakrishnan Ambravaneswaran, Ian Y. Wong, Alexander J. Aranyosi, Mehmet Toner, and Daniel Irimia. Directional decisions during neutrophil chemotaxis inside bifurcating channels. INTEGRATIVE BIOLOGY, 2(11-12):639-647, 2010. [ DOI ]
- Bartholomew J. Kane, George Younan, Douglas Helm, Pouya Dastouri, Harrison Prentice-Mott, Daniel Irimia, Rodney K. Chan, Mehmet Toner, and Dennis P. Orgill. Controlled induction of distributed microdeformation in wounded tissue via a microchamber array dressing. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 95A(2):333-340, NOV 2010. [ DOI ]
- Kenneth T. Kotz, Wenzong Xiao, Carol Miller-Graziano, Wei-Jun Qian, Aman Russom, Elizabeth A. Warner, Lyle L. Moldawer, Asit De, Paul E. Bankey, Brianne O. Petritis, David G. Camp, II, Alan E. Rosenbach, Jeremy Goverman, Shawn P. Fagan, Bernard H. Brownstein, Daniel Irimia, Weihong Xu, Julie Wilhelmy, Michael N. Mindrinos, Richard D. Smith, Ronald W. Davis, Ronald G. Tompkins, Mehmet Toner, and Inflammation Host Response Injury. Clinical microfluidics for neutrophil genomics and proteomics. NATURE MEDICINE, 16(9):1042-U142, SEP 2010. [ DOI ]
Kathryn L. Butler, Vijayakrishnan Ambravaneswaran, Nitin Agrawal, Maryelizabeth Bilodeau, Mehmet Toner, Ronald G. Tompkins, Shawn Fagan, and Daniel Irimia. Burn Injury Reduces Neutrophil Directional Migration Speed in Microfluidic Devices. PLOS ONE, 5(7), JUL 30 2010. [ DOI ]
- R. J. Lee, S. L. Stott, S. Nagrath, L. E. Ulkus, D. M. Dahl, M. R. Smith, M. Toner, S. Maheswaran, and D. A. Haber. Analyses of circulating tumor cell (CTC) dynamics and treatment response in prostate cancer using the CTC-chip microfluidic device. JOURNAL OF CLINICAL ONCOLOGY, 27(15, Suppl. S), MAY 20 2009.
- Cheul H. Cho, Jaesung Park, Arno W. Tilles, Francois Berthiaume, Mehmet Toner, and Martin L. Yarmush. Layered patterning of hepatocytes in co-culture systems using microfabricated stencils. BIOTECHNIQUES, 48(1):47-52, JAN 2010. [ DOI ]
- Shannon L. Stott, Richard J. Lee, Sunitha Nagrath, Min Yu, David T. Miyamoto, Lindsey Ulkus, Elizabeth J. Inserra, Matthew Ulman, Simeon Springer, Zev Nakamura, Alessandra L. Moore, Dina I. Tsukrov, Maria E. Kempner, Douglas M. Dahl, Chin-Lee Wu, A. John Iafrate, Matthew R. Smith, Ronald G. Tompkins, Lecia V. Sequist, Mehmet Toner, Daniel A. Haber, and Shyamala Maheswaran. Isolation and Characterization of Circulating Tumor Cells from Patients with Localized and Metastatic Prostate Cancer. SCIENCE TRANSLATIONAL MEDICINE, 2(25), MAR 31 2010. [ DOI ]
- John Oakey, Robert W. Applegate, Jr., Erik Arellano, Dino Di Carlo, Steven W. Graves, and Mehmet Toner. Particle Focusing in Staged Inertial Microfluidic Devices for Flow Cytometry. ANALYTICAL CHEMISTRY, 82(9):3862-3867, MAY 1 2010. [ DOI ]
- Yevgeny Berdichevsky, Kevin J. Staley, and Martin L. Yarmush. Building and manipulating neural pathways with microfluidics. LAB ON A CHIP, 10(8):999-1004, 2010. [ DOI ]
- Anita Wolfer, Ben S. Wittner, Daniel Irimia, Richard J. Flavin, Mathieu Lupien, Ruwanthi N. Gunawardane, Clifford A. Meyer, Eric S. Lightcap, Pablo Tamayo, Jill P. Mesirov, X. Shirley Liu, Toshi Shioda, Mehmet Toner, Massimo Loda, Myles Brown, Joan S. Brugge, and Sridhar Ramaswamy. MYC regulation of a "poor-prognosis" metastatic cancer cell state. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(8):3698-3703, FEB 23 2010. [ DOI ]
- Erkin Seker, Yevgeny Berdichevsky, Matthew R. Begley, Michael L. Reed, Kevin J. Staley, and Martin L. Yarmush. The fabrication of low-impedance nanoporous gold multiple-electrode arrays for neural electrophysiology studies. NANOTECHNOLOGY, 21(12), MAR 26 2010. [ DOI ]
- Ramin Haghgooie, Mehmet Toner, and Patrick S. Doyle. Squishy Non-Spherical Hydrogel Microparticles. MACROMOLECULAR RAPID COMMUNICATIONS, 31(2, Sp. Iss. SI):128-134, JAN 18 2010. [ DOI ]
- Chihchen Chen, Johan Skog, Chia-Hsien Hsu, Ryan T. Lessard, Leonora Balaj, Thomas Wurdinger, Bob S. Carter, Xandra O. Breakefield, Mehmet Toner, and Daniel Irimia. Microfluidic isolation and transcriptome analysis of serum microvesicles. LAB ON A CHIP, 10(4):505-511, 2010. [ DOI ]
- Grace D. Chen, Catharina J. Alberts, William Rodriguez, and Mehmet Toner. Concentration and Purification of Human Immunodeficiency Virus Type 1 Virions by Microfluidic Separation of Superparamagnetic Nanoparticles. ANALYTICAL CHEMISTRY, 82(2):723-728, JAN 15 2010. [ DOI ]
2009
- Yang, E., Yarmush, M. L., and Androulakis, I. P. (2009) Transcription factor network reconstruction using the living cell array. <em 256, 393-407
- Watkins, N., Venkatesan, B. M., Toner, M., Rodriguez, W., and Bashir, R. (2009) A robust electrical microcytometer with 3-dimensional hydrofocusing. Lab Chip 9, 3177-3184
- Stoothoff, W., Jones, P. B., Spires-Jones, T. L., Joyner, D., Chhabra, E., Bercury, K., Fan, Z., Xie, H., Bacskai, B., Edd, J., Irimia, D., and Hyman, B. T. (2009) Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. J Neurochem 111, 417-427
- Sequist, L. V., Nagrath, S., Toner, M., Haber, D. A., and Lynch, T. J. (2009) The CTC-chip: an exciting new tool to detect circulating tumor cells in lung cancer patients. J Thorac Oncol 4, 281-283
- Maguire, T. J., Novik, E., Chao, P., Barminko, J., Nahmias, Y., Yarmush, M. L., and Cheng, K. C. (2009) Design and application of microfluidic systems for in vitro pharmacokinetic evaluation of drug candidates. Curr Drug Metab 10, 1192-1199
- Kidambi, S., Yarmush, R. S., Novik, E., Chao, P., Yarmush, M. L., and Nahmias, Y. (2009) Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance. Proc Natl Acad Sci USA 106, 15714-15719
- Hwang, D. K., Oakey, J., Toner, M., Arthur, J. A., Anseth, K. S., Lee, S., Zeiger, A., Van Vliet, K. J., and Doyle, P. S. (2009) Stop-flow lithography for the production of shape-evolving degradable microgel particles. J Am Chem Soc 131, 4499-4504
- Guillemette, M. D., Cui, B., Roy, E., Gauvin, R., Giasson, C. J., Esch, M. B., Carrier, P., Deschambeault, A., Dumoulin, M., Toner, M., Germain, L., Veres, T., and Auger, F. A. (2009) Surface topography induces 3D self-orientation of cells and extracellular matrix resulting in improved tissue function. Integr Biol (Camb) 1, 196-204
- Berdichevsky, Y., Staley, K. J., and Yarmush, M. L. (2010) Building and manipulating neural pathways with microfluidics. Lab Chip 10, 999-1004
- Yarmush, M. L., and King, K. R. (2009) Living-cell microarrays. Annu Rev Biomed Eng 11, 235-257
- Yagi, H., Parekkadan, B., Suganuma, K., Soto-Gutierrez, A., Tompkins, R. G., Tilles, A. W., and Yarmush, M. L. (2009) Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure. Tissue Eng Part A 15, 3377-3388
- Russom, A., Irimia, D., and Toner, M. (2009) Chemical gradient-mediated melting curve analysis for genotyping of SNPs. Electrophoresis 30, 2536-2543
- Russom, A., Gupta, A. K., Nagrath, S., Di Carlo, D., Edd, J. F., and Toner, M. (2009) Differential inertial focusing of particles in curved low-aspect-ratio microchannels. New J Phys 11, 75025
- Roach, K. L., King, K. R., Uygun, K., Hand, S. C., Kohane, I. S., Yarmush, M. L., and Toner, M. (2009) High-throughput single cell arrays as a novel tool in biopreservation. Cryobiology 58, 315-321
- Roach, K. L., King, K. R., Uygun, B. E., Kohane, I. S., Yarmush, M. L., and Toner, M. (2009) High throughput single cell bioinformatics. Biotechnol Prog 25, 1772-1779
- Jayaraman, A., Maguire, T., Vemula, M., Kwon, D. W., Vannucci, M., Berthiaume, F., and Yarmush, M. L. (2009) Gene expression profiling of long-term changes in rat liver following burn injury. J Surg Res 152, 3-17,17 e11-12
- Irimia, D., and Toner, M. (2009) Spontaneous migration of cancer cells under conditions of mechanical confinement. Integr Biol (Camb) 1, 506-512
- Irimia, D., Mindrinos, M., Russom, A., Xiao, W., Wilhelmy, J., Wang, S., Heath, J. D., Kurn, N., Tompkins, R. G., Davis, R. W., and Toner, M. (2009) Genome-wide transcriptome analysis of 150 cell samples. Integr Biol (Camb) 1, 99-107
- Irimia, D., Balazsi, G., Agrawal, N., and Toner, M. (2009) Adaptive-control model for neutrophil orientation in the direction of chemical gradients. Biophys J 96, 3897-3916
- Irimia, D. (2009) Cutting edge: electronic counting of white blood cells. Lab Chip 9, 2875-2876
- Edd, J. F., Humphry, K. J., Irimia, D., Weitz, D. A., and Toner, M. (2009) Nucleation and solidification in static arrays of monodisperse drops. Lab Chip 9, 1859-1865
- Di Carlo, D., Edd, J. F., Humphry, K. J., Stone, H. A., and Toner, M. (2009) Particle segregation and dynamics in confined flows. Phys Rev Lett 102, 094503
- Cheng, X., Gupta, A., Chen, C., Tompkins, R. G., Rodriguez, W., and Toner, M. (2009) Enhancing the performance of a point-of-care CD4+ T-cell counting microchip through monocyte depletion for HIV/AIDS diagnostics. Lab Chip 9, 1357-1364
- Chao, P., Maguire, T., Novik, E., Cheng, K. C., and Yarmush, M. L. (2009) Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human. Biochem Pharmacol 78, 625-632
- Berdichevsky, Y., Sabolek, H., Levine, J. B., Staley, K. J., and Yarmush, M. L. (2009) Microfluidics and multielectrode array-compatible organotypic slice culture method. J Neurosci Methods 178, 59-64
- Kenneth L. Roach, Kevin R. King, Basak E. Uygun, Isaac S. Kohane, Martin L. Yarmush, and Mehmet Toner. High Throughput Single Cell Bioinformatics.BIOTECHNOLOGY PROGRESS, 25(6):1772-1779, NOV-DEC 2009. [ DOI ]
- Martin L. Yarmush and Kevin R. King. Living-Cell Microarrays. ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 11:235-257, 2009. [ DOI ]
- Nicholas Watkins, Bala Murali Venkatesan, Mehmet Toner, William Rodriguez, and Rashid Bashir. A robust electrical microcytometer with 3-dimensional hydrofocusing.LAB ON A CHIP, 9(22):3177-3184, 2009. [ DOI ]
- Srivatsan Kidambi, Rubin S. Yarmush, Eric Novik, Piyun Chao, Martin L. Yarmush, and Yaakov Nahmias. Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(37):15714-15719, SEP 15 2009. [ DOI ]
- Daniel Irimia and Mehmet Toner. Spontaneous migration of cancer cells under conditions of mechanical confinement. INTEGRATIVE BIOLOGY, 1(8-9):506-512, 2009. [ DOI ]
- Aman Russom, Daniel Irimia, and Mehmet Toner. Chemical gradient-mediated melting curve analysis for genotyping of SNPs. ELECTROPHORESIS, 30(14):2536-2543, JUL 2009. [ DOI ]
- P. Chao, T. Maguire, E. Novik, K. C. Cheng, and M. L. Yarmush. Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human. BIOCHEMICAL PHARMACOLOGY, 78(6):625-632, SEP 15 2009. [ DOI ]
- Aman Russom, Amit K. Gupta, Sunitha Nagrath, Dino Di Carlo, Jon F. Edd, and Mehmet Toner. Differential inertial focusing of particles in curved low-aspect-ratio microchannels. NEW JOURNAL OF PHYSICS, 11, JUL 31 2009. [ DOI ]
- Xuanhong Cheng, Amit Gupta, Chihchen Chen, Ronald G. Tompkins, William Rodriguez, and Mehmet Toner. Enhancing the performance of a point-of-care CD4+T-cell counting microchip through monocyte depletion for HIV/AIDS diagnostics. LAB ON A CHIP, 9(10):1357-1364, MAY 21 2009. [ DOI ]
- Sihong Wang, Pohun C. Chen, Francois Berthiaume, Mehmet Toner, Arul Jayaraman, and Martin L. Yarmush. Dynamic Effect of Heat Shock Pretreatment on Apoptotic Responses to TNF-alpha in Liver Cells. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 131(7), JUL 2009. [ DOI ]
- Jon F. Edd, Katherine J. Humphry, Daniel Irimia, David A. Weitz, and Mehmet Toner. Nucleation and solidification in static arrays of monodisperse drops. LAB ON A CHIP, 9(13):1859-1865, 2009. [ DOI ]
- Daniel Irimia, Michael Mindrinos, Aman Russom, Wenzhong Xiao, Julie Wilhelmy, Shenglong Wang, Joe Don Heath, Nurith Kurn, Ronald G. Tompkins, Ronald W. Davis, and Mehmet Toner. Genome-wide transcriptome analysis of 150 cell samples. INTEGRATIVE BIOLOGY, 1(1):99-107, JAN 2009. [ DOI ]
- Maxime D. Guillemette, Bo Cui, Emmanuel Roy, Robert Gauvin, Claude J. Giasson, Mandy B. Esch, Patrick Carrier, Alexandre Deschambeault, Michel Dumoulin, Mehmet Toner, Lucie Germain, Teodor Veres, and Francois A. Auger. Surface topography induces 3D self-orientation of cells and extracellular matrix resulting in improved tissue function. INTEGRATIVE BIOLOGY, 1(2):196-204, FEB 2009. [ DOI ]
- Kenneth L. Roach, Kevin R. King, Korkut Uygun, Steven C. Hand, Isaac S. Kohane, Martin L. Yarmush, and Mehmet Toner. High-throughput single cell arrays as a novel tool in biopreservation. CRYOBIOLOGY, 58(3):315-321, JUN 2009. [ DOI ]
- Daniel Irimia, Gabor Balazsi, Nitin Agrawal, and Mehmet Toner. Adaptive-Control Model for NeutrophilOrientation in the Direction of Chemical Gradients. BIOPHYSICAL JOURNAL, 96(10):3897-3916, MAY 20 2009. [ DOI ]
- Dae Kun Hwang, John Oakey, Mehmet Toner, Jeffrey A. Arthur, Kristi S. Anseth, Sunyoung Lee, Adam Zeiger, Krystyn J. Van Vliet, and Patrick S. Doyle. Stop-Flow Lithography for the Production of Shape-Evolving Degradable Microgel Particles. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131(12):4499-4504, APR 1 2009. [ DOI ]
- Dino Di Carlo, Jon F. Edd, Katherine J. Humphry, Howard A. Stone, and Mehmet Toner. Particle Segregation and Dynamics in Confined Flows. PHYSICAL REVIEW LETTERS, 102(9), MAR 6 2009. [ DOI ]
- Yevgeny Berdichevsky, Helen Sabolek, John B. Levine, Kevin J. Staley, and Martin L. Yarmush. Microfluidics and multielectrode array-compatible organotypic slice culture method. JOURNAL OF NEUROSCIENCE METHODS, 178(1):59-64, MAR 30 2009. [ DOI ]
- Lecia V. Sequist, Sunitha Nagrath, Mehmet Toner, Daniel A. Haber, and Thomas J. Lynch. The CTC-Chip An Exciting New Tool to Detect Circulating Tumor Cells in Lung Cancer Patients. JOURNAL OF THORACIC ONCOLOGY, 4(3):281-283, MAR 2009.
- Eric Yang, Martin L. Yarmush, and Ioannis P. Androulakis. Transcription factor network reconstruction using the living cell array. JOURNAL OF THEORETICAL BIOLOGY, 256(3):393-407, FEB 7 2009. [ DOI ]
2008
- Park, K., Jang, J., Irimia, D., Sturgis, J., Lee, J., Robinson, J. P., Toner, M., and Bashir, R. (2008) 'Living cantilever arrays' for characterization of mass of single live cells in fluids. Lab Chip 8, 1034-1041
- Park, J., Li, Y., Berthiaume, F., Toner, M., Yarmush, M. L., and Tilles, A. W. (2008) Radial flow hepatocyte bioreactor using stacked microfabricated grooved substrates. Biotechnol Bioeng 99, 455-467
- Nery, F. C., Zeng, J., Niland, B. P., Hewett, J., Farley, J., Irimia, D., Li, Y., Wiche, G., Sonnenberg, A., and Breakefield, X. O. (2008) TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton. J Cell Sci 121, 3476-3486
- Moore, R. N., Dasgupta, A., Rajaei, N., Yarmush, M. L., Toner, M., Larue, L., and Moghe, P. V. (2008) Enhanced differentiation of embryonic stem cells using co-cultivation with hepatocytes. Biotechnol Bioeng 101, 1332-1343
- Maheswaran, S., Sequist, L. V., Nagrath, S., Ulkus, L., Brannigan, B., Collura, C. V., Inserra, E., Diederichs, S., Iafrate, A. J., Bell, D. W., Digumarthy, S., Muzikansky, A., Irimia, D., Settleman, J., Tompkins, R. G., Lynch, T. J., Toner, M., and Haber, D. A. (2008) Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med 359, 366-377
- Kelly, R. T., Tang, K., Irimia, D., Toner, M., and Smith, R. D. (2008) Elastomeric microchip electrospray emitter for stable cone-jet mode operation in the nanoflow regime. Anal Chem 80, 3824-3831
- Kasuga, K., Yang, R., Porter, T. F., Agrawal, N., Petasis, N. A., Irimia, D., Toner, M., and Serhan, C. N. (2008) Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. J Immunol 181, 8677-8687
- Huang, R., Barber, T. A., Schmidt, M. A., Tompkins, R. G., Toner, M., Bianchi, D. W., Kapur, R., and Flejter, W. L. (2008) A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women. Prenat Diagn 28, 892-899
- Prabhakarpandian, B., Pant, K., Scott, R. C., Patillo, C. B., Irimia, D., Kiani, M. F., and Sundaram, S. (2008) Synthetic microvascular networks for quantitative analysis of particle adhesion. Biomed Microdevices 10, 585-595
- Ahmed, T., and Stocker, R. (2008) Experimental verification of the behavioral foundation of bacterial transport parameters using microfluidics. Biophys J 95, 4481-4493
- Wang, S., Nagrath, D., Chen, P. C., Berthiaume, F., and Yarmush, M. L. (2008) Three-dimensional primary hepatocyte culture in synthetic self-assembling peptide hydrogel. Tissue Eng Part A 14, 227-236
- Wallenstein, E. J., Barminko, J., Schloss, R. S., and Yarmush, M. L. (2008) Transient gene delivery for functional enrichment of differentiating embryonic stem cells. Biotechnol Bioeng 101, 859-872
- Vu, H. N., Li, Y., Casali, M., Irimia, D., Megeed, Z., and Yarmush, M. L. (2008) A microfluidic bioreactor for increased active retrovirus output. Lab Chip 8, 75-80
- Toner, M., and Tompkins, R. G. (2008) Invention, innovation, entrepreneurship in academic medical centers. Surgery 143, 168-171
- Russom, A., Sethu, P., Irimia, D., Mindrinos, M. N., Calvano, S. E., Garcia, I., Finnerty, C., Tannahill, C., Abouhamze, A., Wilhelmy, J., Lopez, M. C., Baker, H. V., Herndon, D. N., Lowry, S. F., Maier, R. V., Davis, R. W., Moldawer, L. L., Tompkins, R. G., and Toner, M. (2008) Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. Clin Chem 54, 891-900
- Novik, E. I., Barminko, J., Maguire, T. J., Sharma, N., Wallenstein, E. J., Schloss, R. S., and Yarmush, M. L. (2008) Augmentation of EB-directed hepatocyte-specific function via collagen sandwich and SNAP. Biotechnol Prog 24, 1132-1141
- Nahmias, Y., Goldwasser, J., Casali, M., van Poll, D., Wakita, T., Chung, R. T., and Yarmush, M. L. (2008) Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin. Hepatology 47, 1437-1445
- King, K. R., Wang, S., Jayaraman, A., Yarmush, M. L., and Toner, M. (2008) Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments. Lab Chip 8, 107-116
- Hsu, C. H., Di Carlo, D., Chen, C., Irimia, D., and Toner, M. (2008) Microvortex for focusing, guiding and sorting of particles. Lab Chip 8, 2128-2134
- Edd, J. F., Di Carlo, D., Humphry, K. J., Koster, S., Irimia, D., Weitz, D. A., and Toner, M. (2008) Controlled encapsulation of single-cells into monodisperse picolitre drops. Lab Chip 8, 1262-1264
- Di Carlo, D., Edd, J. F., Irimia, D., Tompkins, R. G., and Toner, M. (2008) Equilibrium separation and filtration of particles using differential inertial focusing. Anal Chem 80, 2204-2211
- Cho, C. H., Berthiaume, F., Tilles, A. W., and Yarmush, M. L. (2008) A new technique for primary hepatocyte expansion in vitro. Biotechnol Bioeng 101, 345-356
- Agrawal, N., Toner, M., and Irimia, D. (2008) Neutrophil migration assay from a drop of blood. Lab Chip 8, 2054-2061
- Toner, M. (2007) Development of new therapeutic applications using microfluidics. J Vis Exp, 323
- Nitin Agrawal, Mehmet Toner, and Daniel Irimia. Neutrophil migration assay from a drop of blood. LAB ON A CHIP, 8(12):2054-2061, 2008. [ DOI ]
- Chia-Hsien Hsu, Dino Di Carlo, Chihchen Chen, Daniel Irimia, and Mehmet Toner. Microvortex for focusing, guiding and sorting of particles. LAB ON A CHIP, 8(12):2128-2134, 2008. [ DOI ]
- Kie Kasuga, Rong Yang, Timothy F. Porter, Nitin Agrawal, Nicos A. Petasis, Daniel Irimia, Mehmet Toner, and Charles N. Serhan. Rapid Appearance of Resolvin Precursors in Inflammatory Exudates: Novel Mechanisms in Resolution. JOURNAL OF IMMUNOLOGY, 181(12):8677-8687, DEC 15 2008.
- Hiroshi Yagi, Kazuhiro Suganuma, Biju Parekkadan, Alejan-dro Soto-Gutierrez, Yuko Kitagawa, Masaki Kitajima, Mehmet Toner, Ronald G. Tompkins, Francois Berthiaume, Arno W. Tilles, and Martin L. Yarmush. THERAPEUTIC POTENTIAL OF HUMAN BONE MARROW-DERIVED STEM CELL BASED LIVER-ASSIST DEVICE FOR FULMINANT HEPATIC FAILURE. HEPATOLOGY, 48(4, Suppl. S):33, OCT 2008.
- Hiroshi Yogi, Kazuhiro Suganumo, Biju Parekkadan, Alejandro Soto-Gutierrez, Yuko Kitagawa, Masaki Kitajima, Mehmet Toner, Ronald G. Tompkins, Francois Berthiaume, Arno W. Tilles, and Martin L. Yarmush. THERAPEUTIC POTENTIAL OF HUMAN BONE MARROW-DERIVED STEM CELL BASED LIVER-ASSIST DEVICE FOR FULMINANT HEPATIC FAILURE. HEPATOLOGY, 48(4, Suppl. S):288, OCT 2008.
- Rebecca N. Moore, Anouska Dasgupta, Nayyereh Rajaei, Martin L. Yarmush, Mehmet Toner, Lionel Larue, and Prabhas V. Moghe. Enhanced Differentiation of Embryonic Stem Cells Using Co-Cultivation With Hepatocytes. BIOTECHNOLOGY AND BIOENGINEERING, 101(6):1332-1343, DEC 15 2008. [ DOI ]
- R. Huang, T. A. Barber, M. A. Schmidt, R. G. Tompkins, M. Toner, D. W. Bianchi, R. Kapur, and W. L. Flejter. A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women. PRENATAL DIAGNOSIS, 28(10):892-899, OCT 2008. [ DOI ]
- Jon F. Edd, Dino Di Carlo, Katherine J. Humphry, Sarah Koster, Daniel Irimia, David A. Weitz, and Mehmet Toner. Controlled encapsulation of single-cells into monodisperse picolitre drops. LAB ON A CHIP, 8(8):1262-1264, AUG 2008. [ DOI ]
- Shyamala Maheswaran, Lecia V. Sequist, Sunitha Nagrath, Lindsey Ulkus, Brian Brannigan, Chey V. Collura, Elizabeth Inserra, Sven Diederichs, A. John Iafrate, Daphne W. Bell, Subba Digumarthy, Alona Muzikansky, Daniel Irimia, Jeffrey Settleman, Ronald G. Tompkins, Thomas J. Lynch, Mehmet Toner, and Daniel A. Haber. Detection of mutations in EGFR in circulating lung-cancer cells. NEW ENGLAND JOURNAL OF MEDICINE, 359(4):366-377, JUL 24 2008. [ DOI ]
- Kidong Park, Jaesung Jang, Daniel Irimia, Jennifer Sturgis, James Lee, J. Paul Robinson, Mehmet Toner, and Rashid Bashir. `Living cantilever arrays' for characterization of mass of single live cells in fluids. LAB ON A CHIP, 8(7):1034-1041, 2008. [ DOI ]
- Biju Parekkadan, Yevgeny Berdichevsky, Daniel Irimia, Avrum Leeder, Gabriel Yarmush, Mehmet Toner, John B. Levine, and Martin L. Yarmush. Cell-cell interaction modulates neuroectodermal specification of embryonic stem cells. NEUROSCIENCE LETTERS, 438(2):190-195, JUN 20 2008. [ DOI ]
- Ryan T. Kelly, Keqi Tang, Daniel Irimia, Mehmet Toner, and Richard D. Smith. Elastomeric microchip electrospray emitter for stable cone-jet mode operation in the nanoflow regime. ANALYTICAL CHEMISTRY, 80(10):3824-3831, MAY 15 2008. [ DOI ]
- Yaakov Nahmias, Jonathan Goldwasser, Monica Casali, Daan van Poll, Takaji Wakita, Raymond T. Chung, and Martin L. Yarmush. Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin. HEPATOLOGY, 47(5):1437-1445, MAY 2008. [ DOI ]
- Aman Russom, Palaniappan Sethu, Daniel Irimia, Michael N. Mindrinos, Steve E. Calvan, Iris Garcia, Celeste Finnerty, Cynthia Tannahill, Amer Abouhamze, Julie Wilhelmy, M. Cecilia Lopez, Henry V. Baker, David N. Herndon, Stephen F. Lowry, Ronald V. Maier, Ronald W. Davis, Lyle L. Moldawer, Ronald G. Tompkins, Mehmet Toner, and Inflammation Host Response Injury. Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. CLINICAL CHEMISTRY, 54(5):891-900, MAY 2008. [ DOI ]
- Dino Di Carlo, Jon F. Edd, Daniel Irimia, Ronald G. Tompkins, and Mehmet Toner. Equilibrium separation and filtration of particles using differential inertial focusing.ANALYTICAL CHEMISTRY, 80(6):2204-2211, MAR 15 2008. [ DOI ]
- Jaesung Park, Yawen Li, Francois Berthiaume, Mehmet Toner, Martin L. Yarmush, and Arno W. Tilles. Radial flow hepatocyte bioreactor using stacked microfabricated grooved substrates. BIOTECHNOLOGY AND BIOENGINEERING, 99(2):455-467, FEB 1 2008. [ DOI ]
- Halong N. Vu, Yawen Li, Monica Casali, Daniel Irimia, Zaki Megeed, and Martin L. Yarmush. A microfluidic bioreactor for increased active retrovirus output. LAB ON A CHIP, 8(1):75-80, 2008. [ DOI ]
- Kevin R. King, Sihong Wang, Arul Jayaraman, Martin L. Yarmush, and Mehmet Toner. Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments. LAB ON A CHIP, 8(1):107-116, 2008. [ DOI ]
2007
- Yang, E., Maguire, T., Yarmush, M. L., Berthiaume, F., and Androulakis, I. P. (2007) Bioinformatics analysis of the early inflammatory response in a rat thermal injury model. BMC Bioinformatics 8, 10
- Yang, E., Foteinou, P. T., King, K. R., Yarmush, M. L., and Androulakis, I. P. (2007) A novel non-overlapping bi-clustering algorithm for network generation using living cell array data. Bioinformatics 23, 2306-2313
- Pregibon, D. C., Toner, M., and Doyle, P. S. (2007) Multifunctional encoded particles for high-throughput biomolecule analysis. Science 315, 1393-1396
- Cheng, X., Liu, Y. S., Irimia, D., Demirci, U., Yang, L., Zamir, L., Rodriguez, W. R., Toner, M., and Bashir, R. (2007) Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices. Lab Chip 7, 746-755
- Cheng, X., Irimia, D., Dixon, M., Ziperstein, J. C., Demirci, U., Zamir, L., Tompkins, R. G., Toner, M., and Rodriguez, W. R. (2007) A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings. J Acquir Immune Defic Syndr 45, 257-261
- Park, J., Cho, C. H., Parashurama, N., Li, Y., Berthiaume, F., Toner, M., Tilles, A. W., and Yarmush, M. L. (2007) Microfabrication-based modulation of embryonic stem cell differentiation. Lab Chip 7, 1018-1028
- Parekkadan, B., Sethu, P., van Poll, D., Yarmush, M. L., and Toner, M. (2007) Osmotic selection of human mesenchymal stem/progenitor cells from umbilical cord blood. Tissue Eng 13, 2465-2473
- Nahmias, Y., Berthiaume, F., and Yarmush, M. L. (2007) Integration of technologies for hepatic tissue engineering. Adv Biochem Eng Biotechnol 103, 309-329
- Nagrath, S., Sequist, L. V., Maheswaran, S., Bell, D. W., Irimia, D., Ulkus, L., Smith, M. R., Kwak, E. L., Digumarthy, S., Muzikansky, A., Ryan, P., Balis, U. J., Tompkins, R. G., Haber, D. A., and Toner, M. (2007) Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450, 1235-1239
- Kotz, K., Cheng, X., and Toner, M. (2007) PDMS device fabrication and surface modification. J Vis Exp, 319
- Kotz, K., Cheng, X., and Toner, M. (2007) Cell capture using a microfluidic device. J Vis Exp, 320
- King, K. R., Wang, S., Irimia, D., Jayaraman, A., Toner, M., and Yarmush, M. L. (2007) A high-throughput microfluidic real-time gene expression living cell array. Lab Chip 7, 77-85
- Irimia, D., Charras, G., Agrawal, N., Mitchison, T., and Toner, M. (2007) Polar stimulation and constrained cell migration in microfluidic channels. Lab Chip 7, 1783-1790
- Di Carlo, D., Irimia, D., Tompkins, R. G., and Toner, M. (2007) Continuous inertial focusing, ordering, and separation of particles in microchannels. Proc Natl Acad Sci USA 104, 18892-18897
- Cheng, X., Irimia, D., Dixon, M., Sekine, K., Demirci, U., Zamir, L., Tompkins, R. G., Rodriguez, W., and Toner, M. (2007) A microfluidic device for practical label-free CD4(+) T cell counting of HIV-infected subjects. Lab Chip 7, 170-178
- Dino Di Carlo, Daniel Irimia, Ronald G. Tompkins, and Mehmet Toner. Continuous inertial focusing, ordering, and separation of particles in microchannels. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(48):18892-18897, NOV 27 2007. [ DOI ]
- Sunitha Nagrath, Lecia V. Sequist, Shyamala Maheswaran, Daphne W. Bell, Daniel Irimia, Lindsey Ulkus, Matthew R. Smith, Eunice L. Kwak, Subba Digumarthy, Alona Muzikansky, Paula Ryan, Ulysses J. Balis, Ronald G. Tompkins, Daniel A. Haber, and Mehmet Toner. Isolation of rare circulating tumour cells in cancer patients by microchip technology. NATURE, 450(7173):1235-U10, DEC 20 2007. [ DOI ]
- Kenneth T. Kotz, Aman Russom, Daniel Irimia, Michael Mindrinos, Lyle L. Moldawer, Ronald G. Tompkins, and Mehmet Toner. ANYL 403-Microfluidic immunoaffinity capture cassette for rapid isolation and processing of neutrophils from whole blood. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 234, AUG 19 2007.
- Daniel Irimia, Guillaume Charras, Nitin Agrawal, Timothy Mitchison, and Mehmet Toner. Polar stimulation and constrained cell migration in microfluidic channels. LAB ON A CHIP, 7(12):1783-1790, 2007. [ DOI ]
- Biju Parekkadan, Palaniappan Sethu, Daan Van Poll, Martin L. Yarmush, and Mehmet Toner. Osmotic selection of human mesenchymal stem/progenitor cells from umbilical cord blood. TISSUE ENGINEERING, 13(10):2465-2474, OCT 2007. [ DOI ]
- E. Yang, P. T. Foteinou, K. R. King, M. L. Yarmush, and I. P. Androulakis. A novel non-overlapping bi-clustering algorithm for network generation using living cell array data. BIOINFORMATICS, 23(17):2306-2313, SEP 1 2007. [ DOI ]
- Jaesung Park, Cheul H. Cho, Natesh Parashurama, Yawen Li, Francois Berthiaume, Mehmet Toner, Arno W. Tilles, and Martin L. Yarmush. Microfabrication-based modulation of embryonic stem cell differentiation. LAB ON A CHIP, 7(8):1018-1028, 2007. [ DOI ]
- Xuanhong Cheng, Yi-shao Liu, Daniel Irimia, Utkan Demirci, Liju Yang, Lee Zamir, William R. Rodriguez, Mehmet Toner, and Rashid Bashir. Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices. LAB ON A CHIP, 7(6):746-755, JUN 2007. [ DOI ]
- Xuanhong Cheng, Daniel Irimia, Meredith Dixon, Joshua C. Ziperstein, Utkan Demirci, Lee Zamir, Rionald G. Tompkins, Mehmet Toner, and William R. Rodriguez. A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 45(3):257-261, JUL 1 2007.
- Cheul H. Cho, Jaesung Park, Deepak Nagrath, Arno W. Tilles, Francois Berthiaume, Mehmet Toner, and Martin L. Yarmush. Oxygen uptake rates and liver-specific functions of hepatocyte and 3T3 fibroblast co-cultures. BIOTECHNOLOGY AND BIOENGINEERING, 97(1):188-199, MAY 1 2007. [ DOI ]
- Srivatsan Kidambi, Lufang Sheng, Martin L. Yarmush, Mehmet Toner, Ilsoon Lee, and Christina Chan. Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates. MACROMOLECULAR BIOSCIENCE, 7(3):344-353, MAR 8 2007. [ DOI ]
- Kevin R. King, Sihong Wang, Daniel Irimia, Arul Jayaraman, Mehmet Toner, and Martin L. Yarmush. A high-throughput microfluidic real-time gene expression living cell array. LAB ON A CHIP, 7(1):77-85, 2007. [ DOI ]
- Xuanhong Cheng, Daniel Irimia, Meredith Dixon, Kazuhiko Sekine, Utkan Demirci, Lee Zamir, Ronald G. Tompkins, William Rodriguez, and Mehmet Toner. A microfluidic device for practical label-free CD4+T cell counting of HIV-infected subjects. LAB ON A CHIP, 7(2):170-178, 2007. [ DOI ]
- Daniel C. Pregibon, Mehmet Toner, and Patrick S. Doyle. Multifunctional encoded particles for high-throughput biomolecule analysis. SCIENCE, 315(5817):1393-1396, MAR 9 2007. [ DOI ]
- Yaakov Nahmias, Francois Berthiaume, and Martin L. Yarmush. Integration of technologies for hepatic tissue engineering. In TISSUE ENGINEERING II: BASICS OF TISSUE ENGINEERING AND TISSUE APPLICATIONS, volume 103 of ADVANCES IN BIOCHEMICAL ENGINEERING / BIOTECHNOLOGY, pages 309-329. 2007. [ DOI ]
2006
- Vianello, F., Papeta, N., Chen, T., Kraft, P., White, N., Hart, W. K., Kircher, M. F., Swart, E., Rhee, S., Palu, G., Irimia, D., Toner, M., Weissleder, R., and Poznansky, M. C. (2006) Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol 176, 2902-2914
- Tharp, W. G., Yadav, R., Irimia, D., Upadhyaya, A., Samadani, A., Hurtado, O., Liu, S. Y., Munisamy, S., Brainard, D. M., Mahon, M. J., Nourshargh, S., van Oudenaarden, A., Toner, M. G., and Poznansky, M. C. (2006) Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo. J Leukoc Biol 79, 539-554
- Pregibon, D. C., Toner, M., and Doyle, P. S. (2006) Magnetically and biologically active bead-patterned hydrogels. Langmuir 22, 5122-5128
- Murthy, S. K., Sethu, P., Vunjak-Novakovic, G., Toner, M., and Radisic, M. (2006) Size-based microfluidic enrichment of neonatal rat cardiac cell populations. Biomed Microdevices 8, 231-237
- Mikos, A. G., Herring, S. W., Ochareon, P., Elisseeff, J., Lu, H. H., Kandel, R., Schoen, F. J., Toner, M., Mooney, D., Atala, A., Van Dyke, M. E., Kaplan, D., and Vunjak-Novakovic, G. (2006) Engineering complex tissues. Tissue Eng 12, 3307-3339
- Irimia, D., Liu, S. Y., Tharp, W. G., Samadani, A., Toner, M., and Poznansky, M. C. (2006) Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients. Lab Chip 6, 191-198
- Sethu, P., Sin, A., and Toner, M. (2006) Microfluidic diffusive filter for apheresis (leukapheresis). Lab Chip 6, 83-89
- Sethu, P., Moldawer, L. L., Mindrinos, M. N., Scumpia, P. O., Tannahill, C. L., Wilhelmy, J., Efron, P. A., Brownstein, B. H., Tompkins, R. G., and Toner, M. (2006) Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis. Anal Chem 78, 5453-5461
- Sekine, K., Revzin, A., Tompkins, R. G., and Toner, M. (2006) Panning of multiple subsets of leukocytes on antibody-decorated poly(ethylene) glycol-coated glass slides. J Immunol Methods 313, 96-109
- Rajagopalan, P., Shen, C. J., Berthiaume, F., Tilles, A. W., Toner, M., and Yarmush, M. L. (2006) Polyelectrolyte nano-scaffolds for the design of layered cellular architectures. Tissue Eng 12, 1553-1563
- Kane, B. J., Zinner, M. J., Yarmush, M. L., and Toner, M. (2006) Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes. Anal Chem 78, 4291-4298
- Irimia, D., and Toner, M. (2006) Cell handling using microstructured membranes. Lab Chip 6, 345-352
- Irimia, D., Geba, D. A., and Toner, M. (2006) Universal microfluidic gradient generator. Anal Chem 78, 3472-3477
- Guenat, O. T., Generelli, S., de Rooij, N. F., Koudelka-Hep, M., Berthiaume, F., and Yarmush, M. L. (2006) Development of an array of ion-selective microelectrodes aimed for the monitoring of extracellular ionic activities. Anal Chem 78, 7453-7460
- Antonios G. Mikos, Susan W. Herring, Pannee Ochareon, Jennifer Elisseeff, Helen H. Lu, Rita Kandel, Frederick J. Schoen, Mehmet Toner, David Mooney, Anthony Atala, Mark E. Van Dyke, David Kaplan, and Gordana Vunjak-Novakovic. Engineering complex tissues. TISSUE ENGINEERING, 12(12):3307-3339, DEC 2006.
- Yaakov Nahmias, Yiannos Kramvis, Laurent Barbe, Monica Casali, Francois Berthiaume, and Martin L. Yarmush. A novel formulation of oxygen-carrying matrix enhances liver-specific function of cultured hepatocytes. FASEB JOURNAL, 20(14):2531+, DEC 2006. [ DOI ]
- Jaesung Park, Mehmet Toner, Martin L. Yarmush, and Arno W. Tilles. Microchannel bioreactors for bioartificial liver support. MICROFLUIDICS AND NANOFLUIDICS, 2(6):525-535, NOV 2006. [ DOI ]
- Daan Van Poll, Cenk Sokmensuer, Noor Ahmad, Arno W. Tilles, Francois Berthiaume, Mehmet Toner, and Martin L. Yarmush. Elevated hepatocyte-specific functions in fetal rat hepatocytes co-cultured with adult rat hepatocytes. TISSUE ENGINEERING, 12(10):2965-2973, OCT 2006.
- Olivier T. Guenat, Silvia Generelli, Nicolaas F. de Rooij, Milena Koudelka-Hep, Francois Berthiaume, and Martin L. Yarmush. Development of an array of ion-selective microelectrodes aimed for the monitoring of extracellular ionic activities. ANALYTICAL CHEMISTRY, 78(21):7453-7460, NOV 1 2006. [ DOI ]
- Padmavathy Rajagopalan, Colette J. Shen, Francois Berthiaume, Arno W. Tilles, Mehmet Toner, and Martin L. Yarmush. Polyelectrolyte nano-scaffolds for the design of layered cellular Architectures. TISSUE ENGINEERING, 12(6):1553-1563, JUN 2006.M
- Shashi K. Murthy, Palaniappan Sethu, Gordana Vunjak-Novakovic, Mehmet Toner, and Milica Radisic. Size-based microfluidic enrichment of neonatal rat cardiac cell populations. BIOMEDICAL MICRODEVICES, 8(3):231-237, SEP 2006. [ DOI ]
- Kazuhiko Sekine, Alexander Revzin, Ronald G. Tompkins, and Mehmet Toner. Panning of multiple subsets of leukocytes on antibody-decorated poly(ethylene) glycol-coated glass slides. JOURNAL OF IMMUNOLOGICAL METHODS, 313(1-2):96-109, JUN 30 2006. [DOI]
- Palaniappan Sethu, Lyle L. Moldawer, Michael N. Mindrinos, Philip O. Scumpia, Cynthia L. Tannahill, Julie Wilhelmy, Philip A. Efron, Bernard H. Brownstein, Ronald G. Tompkins, and Mehmet Toner. Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis. ANALYTICAL CHEMISTRY, 78(15):5453-5461, AUG 1 2006. [ DOI ]
- F Vianello, N Papeta, T Chen, P Kraft, N White, WK Hart, MF Kircher, E Swart, S Rhee, G Palu, D Irimia, M Toner, R Weissleder, and MC Poznansky. Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control.JOURNAL OF IMMUNOLOGY, 176(5):2902-2914, MAR 1 2006.
- BJ Kane, MJ Zinner, ML Yarmush, and M Toner. Liver-specific functional studies in a microfluidic array of primary mammalian hepatocytes. ANALYTICAL CHEMISTRY, 78(13):4291-4298, JUL 1 2006. [ DOI ]
- DC Pregibon, M Toner, and PS Doyle. Magnetically and biologically active bead-patterned hydrogels. LANGMUIR, 22(11):5122-5128, MAY 23 2006. [ DOI ]
- D Irimia, DA Geba, and M Toner. Universal microfluidic gradient generator. ANALYTICAL CHEMISTRY, 78(10):3472-3477, MAY 15 2006. [ DOI ]
- D Irimia and M Toner. Cell handling using microstructured membranes. LAB ON A CHIP, 6(3):345-352, MAR 2006. [ DOI ]
- D Irimia, SY Liu, WG Tharp, A Samadani, M Toner, and MC Poznansky. Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients. LAB ON A CHIP, 6(2):191-198, FEB 2006. [ DOI ]
- P Sethu, A Sin, and M Toner. Microfluidic diffusive filter for apheresis (leukapheresis). LAB ON A CHIP, 6(1):83-89, 2006. [ DOI ]
- U Demirci and M Toner. Direct etch method for microfludic channel and nanoheight post-fabrication by picoliter droplets. APPLIED PHYSICS LETTERS, 88(5), JAN 30 2006. [ DOI ]
- Y Nahmias, M Casali, L Barbe, F Berthiaume, and ML Yarmush. Liver endothelial cells promote LDL-R expression and the uptake of HCV-like particles in primary rat and human hepatocytes. HEPATOLOGY, 43(2):257-265, FEB 2006. [ DOI ]
2005 and before
- Wieder, K. J., King, K. R., Thompson, D. M., Zia, C., Yarmush, M. L., and Jayaraman, A. (2005) Optimization of reporter cells for expression profiling in a microfluidic device. Biomed Microdevices 7, 213-222
- Cobb, J. P., Mindrinos, M. N., Miller-Graziano, C., Calvano, S. E., Baker, H. V., Xiao, W., Laudanski, K., Brownstein, B. H., Elson, C. M., Hayden, D. L., Herndon, D. N., Lowry, S. F., Maier, R. V., Schoenfeld, D. A., Moldawer, L. L., Davis, R. W., Tompkins, R. G., Baker, H. V., Bankey, P., Billiar, T., Brownstein, B. H., Calvano, S. E., Camp, D., Chaudry, I., Cobb, J. P., Davis, R. W., Elson, C. M., Freeman, B., Gamelli, R., Gibran, N., Harbrecht, B., Hayden, D. L., Heagy, W., Heimbach, D., Herndon, D. N., Horton, J., Hunt, J., Laudanski, K., Lederer, J., Lowry, S. F., Maier, R. V., Mannick, J., McKinley, B., Miller-Graziano, C., Mindrinos, M. N., Minei, J., Moldawer, L. L., Moore, E., Moore, F., Munford, R., Nathens, A., O'Keefe, G., Purdue, G., Rahme, L., Remick, D., Sailors, M., Schoenfeld, D. A., Shapiro, M., Silver, G., Smith, R., Stephanopoulos, G., Stormo, G., Tompkins, R. G., Toner, M., Warren, S., West, M., Wolfe, S., Xiao, W., and Young, V. (2005) Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci USA 102, 4801-4806
- Thompson, D. M., King, K. R., Wieder, K. J., Toner, M., Yarmush, M. L., and Jayaraman, A. (2004) Dynamic gene expression profiling using a microfabricated living cell array. Anal Chem 76, 4098-4103
- Toner, M., and Irimia, D. (2005) Blood-on-a-chip. Annu Rev Biomed Eng 7, 77-103
- Revzin, A., Sekine, K., Sin, A., Tompkins, R. G., and Toner, M. (2005) Development of a microfabricated cytometry platform for characterization and sorting of individual leukocytes. Lab Chip 5, 30-37
- Park, J., Berthiaume, F., Toner, M., Yarmush, M. L., and Tilles, A. W. (2005) Microfabricated grooved substrates as platforms for bioartificial liver reactors. Biotechnol Bioeng 90, 632-644
- Thompson, D. M., King, K. R., Wieder, K. J., Toner, M., Yarmush, M. L., and Jayaraman, A. (2004) Dynamic gene expression profiling using a microfabricated living cell array. Anal Chem 76, 4098-4103
- Sethu, P., Anahtar, M., Moldawer, L. L., Tompkins, R. G., and Toner, M. (2004) Continuous flow microfluidic device for rapid erythrocyte lysis. Anal Chem 76, 6247-6253
- Murthy, S. K., Sin, A., Tompkins, R. G., and Toner, M. (2004) Effect of flow and surface conditions on human lymphocyte isolation using microfluidic chambers. Langmuir 20, 11649-11655
- Irimia, D., Tompkins, R. G., and Toner, M. (2004) Single-cell chemical lysis in picoliter-scale closed volumes using a microfabricated device. Anal Chem 76, 6137-6143;
- Revzin, A., Rajagopalan, P., Tilles, A. W., Berthiaume, F., Yarmush, M. L., and Toner, M. (2004) Designing a hepatocellular microenvironment with protein microarraying and poly(ethylene glycol) photolithography. Langmuir 20, 2999-3005
- KJ Wieder, KR King, DM Thompson, C Zia, ML Yarmush, and A Jayaraman. Optimization of reporter cells for expression profiling in a microfluidic device. BIOMEDICAL MICRODEVICES, 7(3):213-222, SEP 2005. [ DOI ]
- A Sin, SK Murthy, A Revzin, RG Tompkins, and M Toner. Enrichment using antibody-coated microfluidic chambers in shear flow: Model mixtures of human lymphocytes.BIOTECHNOLOGY AND BIOENGINEERING, 91(7):816-826, SEP 30 2005. [ DOI ]
- M Toner and D Irimia. Blood-on-a-chip. ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 7:77-103, 2005. [ DOI ]
- J Park, F Berthiaume, M Toner, ML Yarmush, and AW Tilles. Microfabricated grooved substrates as platforms for bioartificial liver reactors. BIOTECHNOLOGY AND BIOENGINEERING, 90(5):632-644, JUN 5 2005. [ DOI ]
- F Vianello, N Papeta, MF Kircher, M Toner, R Weissleder, D Irimia, and MC Poznansky. Murine melanomas expressing high levels of SDF-1 repel and escape control by tumor specific T-cells. BLOOD, 104(11, Part 1):445, NOV 16 2004.
- LK Sokmensuer, S Palaniappan, M Toner, TL Toth, and DL Wright. A microfluidic chemotaxis system to select motile and mature sperm. FERTILITY AND STERILITY, 82(Suppl. 2):P544, SEP 2004.
- SK Murthy, A Sin, RG Tompkins, and M Toner. Effect of flow and surface conditions on human lymphocyte isolation using microfluidic chambers. LANGMUIR, 20(26):11649-11655, DEC 21 2004. [ DOI ]
- A Revzin, K Sekine, A Sin, RG Tompkins, and M Toner. Development of a microfabricated cytometry platform for characterization and sorting of individual leukocytes. LAB ON A CHIP, 5(1):30-37, 2005. [ DOI ]
- P Sethu, M Anahtar, LL Moldawer, RG Tompkins, and M Toner. Continuous row microfluidic device for rapid erythrocyte lysis. ANALYTICAL CHEMISTRY, 76(21):6247-6253, NOV 1 2004. [ DOI ]
- D Irimia, RG Tompkins, and M Toner. Single-cell chemical lysis in picoliter-scale closed volumes using a microfabricated device. ANALYTICAL CHEMISTRY, 76(20):6137-6143, OCT 15 2004. [ DOI ]
- DM Thompson, KR King, KJ Wieder, M Toner, ML Yarmush, and A Jayaraman. Dynamic gene expression profiling using a microfabricated living cell array. ANALYTICAL CHEMISTRY, 76(14):4098-4103, JUL 15 2004. [ DOI ]
- A Revzin, P Rajagopalan, AW Tilles, FO Berthiaume, ML Yarmush, and M Toner. Designing a hepatocellular microenvironment with protein microarraying and poly(ethylene glycol) photolithography. LANGMUIR, 20(8):2999-3005, APR 13 2004.